业内资讯外讯导读地方动态观点评论权威发布食品科技药监播报每日监管人才资讯法规动态国家法律食品法规地方法规进出境法规国际法规行政许可其它相关法规国家标准进出口行业标准农业标准水产标准商业标准轻工标准地方标准卫生标准化工标准医药标准烟草标准认证认可标准食品安全企业标准其它国内标准团体标准国内标准CAC标准AOAC标准EU/EC欧盟指令条例UNECE标准澳新标准FCC标准JECFA标准其它国外标准国外标准质量管理综合HACCP质量体系ISO质量体系GMP良好操作规范有机食品绿色食品无公害食品非转基因食品认证清真食品认证BRC认证IFS认证GAP认证国外认证食品生产经营许可ISO9001质量管理体系认证ISO14001环境管理体系OHSMS18001职业健康安全管理体系传统管理体系认证HACCP危害分析和关键点体系ISO22000食品安全管理体系乳制品HACCP/GMPFSSC22000食品安全管理体系GAP良好农业规范GLOBALGP全球良好农业规范有机产品BRC英国零售商协会农食认证GB/T50430工程建设施工企业质量管理体系ISO20000信息技术服务管理体系ISO27001信息安全管理体系CCC强制性产品特定管理体系认证溯源业务生态原产地产品保护体系认证法律法规技术培训质量管理职业资格企业管理其他培训培训新闻考试指南培训机构职业相关培训专题报到通知
维护食品安全 构建和谐社会
0431-80812951
微信公众号:CNZAKJ

通知公告      生产    检验   仪器    资料    文库    图库    视频    百科    专利    数据库    学习    翻译    招商    供求    行情    安全    网址    网刊    专题    调查    标签    食话

www.cnzakj.com | www.cnzakj.cn

培根固本 树德铸魂

欧盟评估来自一种转基因地衣芽孢杆菌的1,4-α-麦芽四糖淀粉酶的安全性

2019-06-13 11:25浏览数:126 

2019年5月8日,欧盟食品安全局发布关于来自基因地衣芽孢杆菌(菌株DP‐Dzr46)的1,4-α-麦芽四糖淀粉酶(1,4‐α‐maltotetraohydrolase)安全性的评估结果。

  据了解,这种食品酶旨在用于烘焙过程。经过评估,专家小组得出结论,这种食品酶在预期使用条件下不会引起安全问题。
  部分原文报道如下:
  The food enzyme glucan 1,4‐α‐maltotetraohydrolase (4‐α‐d‐glucan maltotetraohydrolase, EC 3.2.1.60) is produced with a genetically modified Bacillus licheniformis strain DP‐Dzr46 by Danisco US Inc. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and recombinant DNA. The glucan 1,4‐α‐maltotetraohydrolase food enzyme is intended to be used in baking processes. based on the maximum use levels, dietary exposure to the food enzyme-Total Organic Solids (TOS) was estimated to be up to 0.405 mg TOS/kg body weight (bw) per day in European populations. The toxicity studies were carried out with another glucan 1,4‐α‐maltotetraohydrolase from B. licheniformis (strain DP‐Dzf24)。 The Panel considered this food enzyme as a suitable substitute to be used in the toxicological studies, because it derives from the same recipient strain as strain DP‐Dzr46, the location of the inserts is comparable, no partial inserts were present and the production methods are comparable. Genotoxicity tests did not raise a safety concern. The systemic toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rats. The Panel identified a no observed adverse effect level (NOAEL) at the highest dose of 94 mg TOS/kg bw per day that, compared with the estimated dietary exposure, results in a sufficiently high margin of exposure of at least 232. Similarity of the amino acid sequence to those of known allergens was searched and none was found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, but the likelihood is considered to be low. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.


最新培训信息
联系我们

电话:0431-80812939 / 51 / 50 / 53 / 58
                  80812960 / 36 / 56 / 57 / 59

邮箱:cnzakj@163.com

手机:18701090480

客服:培训咨询

联系我们:
0431-81772182
联系QQ:277303196
手机号码:13811481445
联系邮箱:zsbzw01@126.com
会员登录
登录
我的资料
留言
回到顶部